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Art therapy. --- Art --- Psychiatry and art --- Occupational therapy --- Psychotherapy --- Art in hospitals --- Therapeutic use --- Teràpia artística --- Assaigs clínics
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This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials. .
Malaltia de Parkinson --- Assaigs clínics --- Assaigs terapèutics --- Estudis clínics --- Estudis terapèutics --- Experimentació humana en medicina --- Paràlisi agitant --- Malalties cerebrals --- Malalties neurodegeneratives --- Neurosciences. --- Neuroscience. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system
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Assaigs clínics --- Assaigs terapèutics --- Estudis clínics --- Estudis terapèutics --- Experimentació humana en medicina --- Clinical trials. --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Research
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This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time.
Clinical trials. --- Statistics. --- Clinical trials --- Statistical methods. --- Statistical analysis --- Statistical data --- Statistical methods --- Statistical science --- Mathematics --- Econometrics --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Research --- Assaigs clínics --- Assaigs terapèutics --- Estudis clínics --- Estudis terapèutics --- Experimentació humana en medicina
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This book provides state-of-art statistical methodologies, practical considerations from regulators and sponsors, logistics, and real use cases for practitioners for the uptake of RWE/D. Randomized clinical trials have been the gold standard for the evaluation of efficacy and safety of medical products. However, the cost, duration, practicality, and limited generalizability have incentivized many to look for alternative ways to optimize drug development. This book provides a comprehensive list of topics together to include all aspects with the uptake of RWE/D, including, but not limited to, applications in regulatory and non-regulatory settings, causal inference methodologies, organization and infrastructure considerations, logistic challenges, and practical use cases.
Clinical trials. --- Drug development. --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Development --- Research --- Statistics. --- Artificial intelligence—Data processing. --- Computer science—Mathematics. --- Data Science. --- Mathematics of Computing. --- Statistical analysis --- Statistical data --- Statistical methods --- Statistical science --- Mathematics --- Econometrics --- Therapeutics --- Medical --- Desenvolupament de medicaments --- Assaigs clínics
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This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. Most chapters have been revised considerably from the fourth edition. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing, and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology. .
Statistics. --- Cancer research. --- Public health. --- Oncology. --- Epidemiology. --- Statistics for Life Sciences, Medicine, Health Sciences. --- Public Health. --- Cancer Research. --- Oncology . --- Tumors --- Statistical analysis --- Statistical data --- Statistical methods --- Statistical science --- Mathematics --- Econometrics --- Diseases --- Public health --- Clinical trials. --- Clinical Trials as Topic. --- Statistics . --- Cancer research --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- Assaigs clínics --- Assaigs terapèutics --- Estudis clínics --- Estudis terapèutics --- Experimentació humana en medicina
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This volume explores current viewpoints and knowledge gaps in the field of traumatic brain injury (TBI). The chapters in this book cover topics ranging from development of in vitro and animal TBI models, to diagnostic imaging and disease monitoring in patients. Designing pre-clinical and clinical trials is also discussed. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Practical and thorough, Pre-Clinical and Clinical Methods in Brain Trauma Research is a valuable resource for both scientists and clinical researchers interested in learning about important techniques and their applications in the field of TBI.
Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Lesions cerebrals --- Assaigs clínics --- Investigació mèdica --- Manuals de laboratori --- Tècniques de laboratori --- Investigació biomèdica --- Investigació --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori --- Assaigs terapèutics --- Estudis clínics --- Estudis terapèutics --- Dany cerebral --- Danys cerebrals --- Disfuncions cerebrals --- Lesió cerebral --- Malalties cerebrals --- Psicopatologia --- Encefalopatia hepàtica --- Estat vegetatiu persistent --- Paràlisi cerebral --- Pacients amb lesions cerebrals
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This book provides a comprehensive review of novel adaptive trial designs for targeted therapies and immunotherapies. This book covers a wide range of novel statistical designs for various clinical settings, including early phase dose-escalation study, proof-of-concept trials, and confirmatory studies with registrational. The book includes real-life examples and software to facilitate practitioners to learn and use the designs in practice.
Biometry. --- Biostatistics. --- Biological statistics --- Biology --- Biometrics (Biology) --- Biostatistics --- Biomathematics --- Statistics --- Statistical methods --- Clinical Trial Protocols as Topic. --- Adaptive Clinical Trials as Topic. --- Bayes Theorem. --- Analysis, Bayesian --- Bayesian Approach --- Bayesian Analysis --- Bayesian Forecast --- Bayesian Method --- Bayesian Prediction --- Approach, Bayesian --- Approachs, Bayesian --- Bayesian Approachs --- Forecast, Bayesian --- Method, Bayesian --- Prediction, Bayesian --- Theorem, Bayes --- Anthropology, Physical --- Statistics as Topic --- Biological Statistics --- Biological Statistic --- Statistic, Biological --- Statistics, Biological --- Adaptive Clinical Trial Design --- Adaptive Clinical Trial as Topic --- Immunoteràpia --- Dianes farmacològiques --- Assaigs clínics --- Estadística matemàtica --- Estadística bayesiana
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This open access book explores the expectations surrounding dementia, what it ‘looks like’ and how people have been treated by others. It aims to raise awareness of the different types of dementia, and how they impact the brain, body, and lived experience, including experience of Alzheimer’s disease, Vascular Dementia, Posterior Cortical Atrophy, Frontotemporal Dementia, Semantic Dementia, and Lewy Body Dementia. The co-authors reflect on their experience with informal and formal care, before finishing with a focus on the spectrum of dementia research from clinical trials to user-led research. Throughout the book, co-authors have shared personal stories of how dementia has affected them and people with lived experience of dementia share what they wish people knew about living with the disease. Co-produced by people with lived experience of dementia, academics and health care professionals, this book is an accessible resource about dementia from the perspective of people actively involved in the field and essential reading for healthcare professionals wishing to learn more about the experience of this neuroprogressive condition, as well as policymakers, and members of the public. Dr Rosie Ashworth leads Partners in Research for NRS Neuroprogressive and Dementia Network, UK. As a research psychologist, Rosie is passionate about co-production, ethics, and actively involving people with lived experience in research. She is also the co-lead for ENRICH Scotlands ‘Patient and Public Involvement’ group RICH (Research in Care Homes) Voices, a Fellow with Advanced Higher Education, an advisor to the Dementia Enquirers, and a volunteer for About Dementia. Partners in Research co-authors including Agnes Houston, Chris Maddocks, David Ross, Fred S. Wilson, Masood Qureshi, Martin Robertson, Myra Lamont, Stuart Hay, Sue Fyvel, Willy Gilder, Winnie Henry, and Alyson Hill.
Geriatrics. --- Clinical psychology. --- Nervous system --- Mental health. --- Clinical health psychology. --- Psychology --- Clinical Psychology. --- Neurological Disorders. --- Mental Health. --- Health Psychology. --- Psychological Methods. --- Diseases. --- Methodology. --- Health psychology --- Health psychology, Clinical --- Psychology, Clinical health --- Psychology, Health --- Salutogenesis --- Clinical psychology --- Medicine and psychology --- Emotional health --- Mental hygiene --- Mental physiology and hygiene --- Happiness --- Health --- Public health --- Mental illness --- Psychiatry --- Psychology, Pathological --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Psychology, Applied --- Psychological tests --- Medicine --- Gerontology --- Older people --- Diseases --- Health and hygiene --- Demència --- Assaigs clínics --- Testimonis
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A significantly expanded third edition, this book provides a comprehensive and concise overview of cardiac arrhythmias and their ECG/telemetry manifestations, including the principles of cardiac electrophysiology, current concepts of pharmacology, clinical features, diagnoses, and state-of-the-art treatments. Additionally, the book emphasizes decision-making strategies in approaching each individual patient and the application of technical innovations in specific clinical situations. Organized into eight parts, beginning chapters introduce the concepts and principles of cardiac electrophysiology, unique rhythms, and ECG waves/signs. These chapters are designed to integrate emerging knowledge in basic science and clinical medicine. Subsequent chapters focus on the diagnosis of a variety of cardiac arrhythmias using non-invasive methodology. Throughout the book, chapters continue to analyze pharmacological and other approaches to therapy of specific arrhythmias, including supraventricular tachycardias, atrial fibrillation and flutter, ventricular arrhythmias, and bradyarrhythmias. Finally, the book closes with coverage on inherited cardiac arrhythmia syndromes including the long, short QT, and J-wave syndromes, catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. The third edition of Management of Cardiac Arrhythmias, is an essential resource for physicians, residents, fellows, and medical students in cardiology, cardiac surgery, vascular surgery, cardiac electrophysiology, and cardiac radiology.
Cardiology. --- Cardiac surgery. --- Cardiac Surgery. --- Cardiac surgery --- Heart --- Open-heart surgery --- Internal medicine --- Diseases --- Surgery --- Surgery. --- Arrítmia --- Farmacologia clínica --- Cardiologia --- Electrocardiografia --- ECG --- EKG --- Electrodiagnòstic --- Electrofisiologia --- Fonocardiografia --- Medicina interna --- Anestèsia en cardiologia --- Cardiologia geriàtrica --- Cardiologia pediàtrica --- Cardiologia veterinària --- Medicina intensiva en cardiologia --- Malalties cardiovasculars --- Malalties del cor --- Malalties vasculars --- Efecte dels medicaments en els éssers humans --- Efectes dels medicaments en els éssers humans --- Farmacologia --- Medicina clínica --- Assaigs clínics de medicaments --- Farmacologia experimental --- Placebos --- Farmacoepidemiologia --- Arítmia --- Al·lorítmia --- Trastorns del ritme cardíac --- Batecs cardíacs --- Aleteig auricular --- Fibril·lació auricular --- Fibril·lació ventricular --- Taquicàrdia --- Antiarrítmics cardíacs
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